Ontology highlight
ABSTRACT:
SUBMITTER: Zhong J
PROVIDER: S-EPMC5103840 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Experimental and therapeutic medicine 20160928 5
Catechol-O-methyltransferase (COMT) gene variation is known to be associated with the risk of acute coronary events. The purpose of the present study was to investigate the contribution of COMT promoter methylation towards the risk of coronary heart disease (CHD). COMT methylation was evaluated in 48 CHD cases and 48 well-matched non-CHD controls using bisulfite pyrosequencing technology. The results demonstrated that CHD cases had a significantly lower level of methylation at COMT CpG3 sites co ...[more]