Ontology highlight
ABSTRACT:
SUBMITTER: Jin J
PROVIDER: S-EPMC5105081 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Jin Jihui J Zhao Jing J Ren Yingchao Y Zhong Qi Q Zhang Guozhong G
Scientific reports 20161111
To evaluate the contribution of length diversity in the hemagglutinin-neuraminidase (HN) protein to the pathogenicity, replication and biological characteristics of Newcastle disease virus (NDV), we used reverse genetics to generate a series of recombinant NDVs containing truncated or extended HN proteins based on an infectious clone of genotype VII NDV (SG10 strain). The mean death times and intracerebral pathogenicity indices of these viruses showed that the different length mutations in the H ...[more]