Ontology highlight
ABSTRACT:
SUBMITTER: van Unen J
PROVIDER: S-EPMC5105084 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
van Unen Jakobus J Yin Taofei T Wu Yi I YI Mastop Marieke M Gadella Theodorus W J TW Goedhart Joachim J
Scientific reports 20161111
Rho GTPases are master regulators of the eukaryotic cytoskeleton. The activation of Rho GTPases is governed by Rho guanine nucleotide exchange factors (GEFs). Three RhoGEF isoforms are produced by the gene ARHGEF25; p63RhoGEF<sup>580</sup>, GEFT and a recently discovered longer isoform of 619 amino acids (p63RhoGEF<sup>619</sup>). The subcellular distribution of p63RhoGEF<sup>580</sup> and p63RhoGEF<sup>619</sup> is strikingly different in unstimulated cells, p63RhoGEF<sup>580</sup> is located a ...[more]