Ontology highlight
ABSTRACT:
SUBMITTER: Pasini S
PROVIDER: S-EPMC5107905 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Scientific reports 20161114
In earlier studies, we showed that ATF4 down-regulation affects post-synaptic development and dendritic spine morphology in neurons through increased turnover of the Rho GTPase Cell Division Cycle 42 (Cdc42) protein. Here, we find that ATF4 down-regulation in both hippocampal and cortical neuron cultures reduces protein and message levels of RhoGDIα, a stabilizer of the Rho GTPases including Cdc42. This effect is rescued by an shATF4-resistant active form of ATF4, but not by a mutant that lacks ...[more]