Ontology highlight
ABSTRACT:
SUBMITTER: Yuan B
PROVIDER: S-EPMC5108879 | biostudies-other | 2016 Dec
REPOSITORIES: biostudies-other
Yuan Baolei B Wang Xingshun X Fan Chunyan C You Jin J Liu Yuchu Y Weber Jason D JD Zhong Hanbing H Zhang Yandong Y
Molecular and cellular biology 20161114 23
The RNA helicase DHX33 has been shown to be a critical regulator of cell proliferation and growth. However, the underlying mechanisms behind DHX33 function remain incompletely understood. We present original evidence in multiple cell lines that DHX33 transcriptionally controls the expression of genes involved in the cell cycle, notably cyclin, E2F1, cell division cycle (CDC), and minichromosome maintenance (MCM) genes. DHX33 physically associates with the promoters of these genes and controls th ...[more]