Ontology highlight
ABSTRACT:
SUBMITTER: Heitman J
PROVIDER: S-EPMC51143 | biostudies-other | 1991 Mar
REPOSITORIES: biostudies-other
Heitman J J Movva N R NR Hiestand P C PC Hall M N MN
Proceedings of the National Academy of Sciences of the United States of America 19910301 5
FK 506 and cyclosporin A are potent immunosuppressive compounds that inhibit T-cell activation by interfering with signal transduction. In vitro, FK 506 binds and inhibits the activity of FK 506-binding protein (FKBP), a peptidylprolyl rotamase (cis-trans isomerase). Cyclosporin A acts similarly on a different proline rotamase, cyclophilin. Experiments described here demonstrate genetically that FKBP is a target for FK 506 in vivo. We have isolated the gene encoding the FKBP proline rotamase (FP ...[more]