Ontology highlight
ABSTRACT:
SUBMITTER: Brandalise F
PROVIDER: S-EPMC5116082 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Brandalise Federico F Carta Stefano S Helmchen Fritjof F Lisman John J Gerber Urs U
Nature communications 20161116
The computational repertoire of neurons is enhanced by regenerative electrical signals initiated in dendrites. These events, referred to as dendritic spikes, can act as cell-intrinsic amplifiers of synaptic input. Among these signals, dendritic NMDA spikes are of interest in light of their correlation with synaptic LTP induction. Because it is not possible to block NMDA spikes pharmacologically while maintaining NMDA receptors available to initiate synaptic plasticity, it remains unclear whether ...[more]