Ontology highlight
ABSTRACT:
SUBMITTER: Lee WW
PROVIDER: S-EPMC5122839 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Lee Wendy W L WW Teo Teck-Hui TH Lum Fok-Moon FM Andiappan Anand K AK Amrun Siti Naqiah SN Rénia Laurent L Rötzschke Olaf O Ng Lisa F P LF
Scientific reports 20161125
The use of IL-2/JES6-1 Ab complex (IL-2 Ab Cx) has been considered as a potential therapeutic for inflammatory diseases due to its selective expansion of regulatory T cells (Tregs) in mice. Here, IL-2 Ab Cx was explored as a therapeutic agent to reduce joint inflammation induced by chikungunya virus, an alphavirus causing debilitating joint disease globally. Virus-infected mice treated with IL-2 Ab Cx exhibited exacerbated joint inflammation due to infiltration of highly activated CD4<sup>+</sup ...[more]