Ontology highlight
ABSTRACT:
SUBMITTER: Iyer SS
PROVIDER: S-EPMC2657829 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Iyer Smita S SS Accardi Carolyn J CJ Ziegler Thomas R TR Blanco Roberto A RA Ritzenthaler Jeffrey D JD Rojas Mauricio M Roman Jesse J Jones Dean P DP
PloS one 20090327 3
<h4>Background</h4>Cysteine (Cys) and its disulfide, cystine (CySS) represent the major extracellular thiol/disulfide redox control system. The redox potential (E(h)) of Cys/CySS is centered at approximately -80 mV in the plasma of healthy adults, and oxidation of E(h) Cys/CySS is implicated in inflammation associated with various diseases.<h4>Methodology/principal findings</h4>The purpose of the present study was to determine whether oxidized E(h) Cys/CySS is a determinant of interleukin (IL)-1 ...[more]