Ontology highlight
ABSTRACT:
SUBMITTER: Ge Z
PROVIDER: S-EPMC5122860 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Ge Zheng Z Gu Yan Y Han Qi Q Zhao Gang G Li Min M Li Jianyong J Chen Baoan B Sun Tianyu T Dovat Sinisa S Gale Robert Peter RP Song Chunhua C
Scientific reports 20161125
Dynamin-2 (DNM2) is a GTPase essential for intracellular vesicle formation and trafficking, cytokinesis and receptor endocytosis. Mutations in DNM2 are common in early T-cell precursor acute lymphoblastic leukemia. However, DNM2 expression in other types of ALL are not reported. We studied DNM2 mRNA level in adults with B- and T-cell ALL. We found DNM2 is more highly expressed compared with normals in both forms of ALL. High DNM2 expression is associated with some clinical and laboratory feature ...[more]