Ontology highlight
ABSTRACT:
SUBMITTER: Cohen-Kaplan V
PROVIDER: S-EPMC5127335 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Cohen-Kaplan Victoria V Livneh Ido I Avni Noa N Fabre Bertrand B Ziv Tamar T Kwon Yong Tae YT Ciechanover Aaron A
Proceedings of the National Academy of Sciences of the United States of America 20161017 47
The ubiquitin-proteasome system and autophagy are the two main proteolytic systems involved in, among other functions, the maintenance of cell integrity by eliminating misfolded and damaged proteins and organelles. Both systems remove their targets after their conjugation with ubiquitin. An interesting, yet incompletely understood problem relates to the fate of the components of the two systems. Here we provide evidence that amino acid starvation enhances polyubiquitination on specific sites of ...[more]