Ontology highlight
ABSTRACT:
SUBMITTER: LaClair KD
PROVIDER: S-EPMC5131701 | biostudies-other | 2016 Dec
REPOSITORIES: biostudies-other
LaClair Katherine D KD Donde Aneesh A Ling Jonathan P JP Jeong Yun Ha YH Chhabra Resham R Martin Lee J LJ Wong Philip C PC
Acta neuropathologica 20161026 6
TDP-43 proteinopathy, initially associated with ALS and FTD, is also found in 30-60% of Alzheimer's disease (AD) cases and correlates with worsened cognition and neurodegeneration. A major component of this proteinopathy is depletion of this RNA-binding protein from the nucleus, which compromises repression of non-conserved cryptic exons in neurodegenerative diseases. To test whether nuclear depletion of TDP-43 may contribute to the pathogenesis of AD cases with TDP-43 proteinopathy, we examined ...[more]