Ontology highlight
ABSTRACT:
SUBMITTER: Bartz JC
PROVIDER: S-EPMC5131755 | biostudies-other | 2016 Dec
REPOSITORIES: biostudies-other
Cold Spring Harbor perspectives in medicine 20161201 12
Prion diseases affect a wide range of mammal species and are caused by a misfolded self-propagating isoform (PrP<sup>Sc</sup>) of the normal prion protein (PrP<sup>C</sup>). Distinct strains of prions exist and are operationally defined by differences in a heritable phenotype under controlled experimental transmission conditions. Prion strains can differ in incubation period, clinical signs of disease, tissue tropism, and host range. The mechanism by which a protein-only pathogen can encode stra ...[more]