Ontology highlight
ABSTRACT:
SUBMITTER: Kim JH
PROVIDER: S-EPMC5133700 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Kim Ji Hyun JH Lee Bo Bae BB Oh Young Mi YM Zhu Chenchen C Steinmetz Lars M LM Lee Yookyeong Y Kim Wan Kyu WK Lee Sung Bae SB Buratowski Stephen S Kim TaeSoo T
Nature communications 20161128
H3K36 methylation by Set2 targets Rpd3S histone deacetylase to transcribed regions of mRNA genes, repressing internal cryptic promoters and slowing elongation. Here we explore the function of this pathway by analysing transcription in yeast undergoing a series of carbon source shifts. Approximately 80 mRNA genes show increased induction upon SET2 deletion. A majority of these promoters have overlapping lncRNA transcription that targets H3K36me3 and deacetylation by Rpd3S to the mRNA promoter. We ...[more]