Ontology highlight
ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC5137225 | biostudies-other | 2016 Dec
REPOSITORIES: biostudies-other
Wang Peng P Li Jingzhi J Sha Bingdong B
Acta crystallographica. Section D, Structural biology 20161129 Pt 12
PERK is one of the major sensor proteins which can detect the protein-folding imbalance generated by endoplasmic reticulum (ER) stress. It remains unclear how the sensor protein PERK is activated by ER stress. It has been demonstrated that the PERK luminal domain can recognize and selectively interact with misfolded proteins but not native proteins. Moreover, the PERK luminal domain may function as a molecular chaperone to directly bind to and suppress the aggregation of a number of misfolded mo ...[more]