Ontology highlight
ABSTRACT:
SUBMITTER: Bleymehl K
PROVIDER: S-EPMC5196021 | biostudies-other | 2016 Dec
REPOSITORIES: biostudies-other
Neuron 20161201 6
Sensing the level of oxygen in the external and internal environments is essential for survival. Organisms have evolved multiple mechanisms to sense oxygen. No function in oxygen sensing has been attributed to any mammalian olfactory system. Here, we demonstrate that low environmental oxygen directly activates a subpopulation of sensory neurons in the mouse main olfactory epithelium. These neurons express the soluble guanylate cyclase Gucy1b2 and the cation channel Trpc2. Low oxygen induces calc ...[more]