Ontology highlight
ABSTRACT:
SUBMITTER: Pritchett BP
PROVIDER: S-EPMC5207349 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Angewandte Chemie (International ed. in English) 20160926 43
The successful application of dihydropyrido[1,2-a]indolone (DHPI) substrates in Pd-catalyzed asymmetric allylic alkylation chemistry facilitates rapid access to multiple alkaloid frameworks in an enantioselective fashion. Strategic bromination at the indole C3 position greatly improved the allylic alkylation chemistry and enabled a highly efficient Negishi cross-coupling downstream. The first catalytic enantioselective total synthesis of (-)-goniomitine, along with divergent formal syntheses of ...[more]