Ontology highlight
ABSTRACT:
SUBMITTER: Latour C
PROVIDER: S-EPMC5210233 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Latour Chloé C Wlodarczyk Myriam F MF Jung Grace G Gineste Aurélie A Blanchard Nicolas N Ganz Tomas T Roth Marie-Paule MP Coppin Hélène H Kautz Léon L
Haematologica 20160922 1
Malaria, a major global health challenge worldwide, is accompanied by a severe anemia secondary to hemolysis and increased erythrophagocytosis. Iron is an essential functional component of erythrocyte hemoglobin and its availability is controlled by the liver-derived hormone hepcidin. We examined the regulation of hepcidin during malarial infection in mice using the rodent parasite Plasmodium berghei K173. Mice infected with Plasmodium berghei K173 develop a severe anemia and die after 18 to 22 ...[more]