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First-line treatment options in metastatic renal cell cancer.

ABSTRACT: The introduction of targeted therapy a decade ago revolutionized the treatment of metastatic renal cell carcinoma (mRCC). The current standard of care focuses on the inhibition of angiogenesis through the targeting of the vascular endothelial growth factor receptor (VEGFR) and the mammalian target of rapamycin (mTOR). Currently recommended first-line treatments in Canada include sunitinib, pazopanib, and temsirolimus. With the heterogeneity of mRCC disease, the choice of treatment is driven largely by prognostic factors.

SUBMITTER: Kapoor A

PROVIDER: S-EPMC5215299 | biostudies-other | 2016 Nov-Dec

REPOSITORIES: biostudies-other

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First-line treatment options in metastatic renal cell cancer.

Kapoor Anil A

Canadian Urological Association journal = Journal de l'Association des urologues du Canada 20161101 11-12Suppl7

The introduction of targeted therapy a decade ago revolutionized the treatment of metastatic renal cell carcinoma (mRCC). The current standard of care focuses on the inhibition of angiogenesis through the targeting of the vascular endothelial growth factor receptor (VEGFR) and the mammalian target of rapamycin (mTOR). Currently recommended first-line treatments in Canada include sunitinib, pazopanib, and temsirolimus. With the heterogeneity of mRCC disease, the choice of treatment is driven larg ...[more]

PMID: 28096934

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