Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC5223173 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Wang Hao H Dai Tingting T Zhou Shuyan S Huang Xiaoxiao X Li Songying S Sun Kang K Zhou Guangdong G Dou Hongjing H
Scientific reports 20170110
In order to overcome the key challenge in improving both fabrication efficiency and their drug delivery capability of anti-cancer drug delivery systems (ACDDS), here polyacrylic acid (PAA) grafted dextran (Dex) nanohydrogels (NGs) with covalent crosslinked structure bearing redox sensitive disulfide crosslinking junctions (Dex-SS-PAA) were synthesized efficiently through a one-step self-assembly assisted methodology (SAA). The Dex-SS-PAA were subsequently conjugated with doxorubicin through an a ...[more]