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Intravital characterization of tumor cell migration in pancreatic cancer.

ABSTRACT: Curing pancreatic cancer is difficult as metastases often determine the poor clinical outcome. To gain more insight into the metastatic behavior of pancreatic cancer cells, we characterized migratory cells in primary pancreatic tumors using intravital microscopy. We visualized the migratory behavior of primary tumor cells of a genetically engineered pancreatic cancer mouse model and found that pancreatic tumor cells migrate with a mesenchymal morphology as single individual cells or collectively as a stream of non-cohesive single motile cells. These findings may improve our ability to conceive treatments that block metastatic behavior.

SUBMITTER: Beerling E

PROVIDER: S-EPMC5226006 | biostudies-other | 2016

REPOSITORIES: biostudies-other

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Intravital characterization of tumor cell migration in pancreatic cancer.

Beerling Evelyne E Oosterom Ilse I Voest Emile E Lolkema Martijn M van Rheenen Jacco J

Intravital 20161118 3

Curing pancreatic cancer is difficult as metastases often determine the poor clinical outcome. To gain more insight into the metastatic behavior of pancreatic cancer cells, we characterized migratory cells in primary pancreatic tumors using intravital microscopy. We visualized the migratory behavior of primary tumor cells of a genetically engineered pancreatic cancer mouse model and found that pancreatic tumor cells migrate with a mesenchymal morphology as single individual cells or collectively ...[more]

PMID: 28243522

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