Changes in DNA Methylation in Mouse Lungs after a Single Intra-Tracheal Administration of Nanomaterials.
Ontology highlight
ABSTRACT:
SUBMITTER: Tabish AM
PROVIDER: S-EPMC5231360 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Publications
Changes in DNA Methylation in Mouse Lungs after a Single Intra-Tracheal Administration of Nanomaterials.
Tabish Ali M AM Poels Katrien K Byun Hyang-Min HM Luyts Katrien K Baccarelli Andrea A AA Martens Johan J Kerkhofs Stef S Seys Sven S Hoet Peter P Godderis Lode L
PloS one 20170112 1
<h4>Aims</h4>This study aimed to investigate the effects of nanomaterial (NM) exposure on DNA methylation.<h4>Methods and results</h4>Intra-tracheal administration of NM: gold nanoparticles (AuNPs) of 5-, 60- and 250-nm diameter; single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) at high dose of 2.5 mg/kg and low dose of 0.25 mg/kg for 48 h to BALB/c mice. Study showed deregulations in immune pathways in NM-induced toxicity in vivo. NM administration had the follo ...[more]
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