Ontology highlight
ABSTRACT:
SUBMITTER: Sun J
PROVIDER: S-EPMC5253699 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Sun Jinghan J Liu Chang C Bai Xiaobing X Li Xiaoting X Li Jingyun J Zhang Zhiping Z Zhang Yunpeng Y Guo Jing J Li Yan Y
Nature communications 20170119
Protein homeostasis is critical for health and lifespan of animals. However, the mechanisms for controlling protein feeding remain poorly understood. Here we report that in Drosophila, protein intake-induced feeding inhibition (PIFI) is specific to protein-containing food, and this effect is mediated by a fat body (FB) peptide named female-specific independent of transformer (FIT). Upon consumption of protein food, FIT expression is greatly elevated. Secreted FIT peptide in the fly haemolymph co ...[more]