Downregulated miR-29a/b/c during Contact Inhibition Stage Promote 3T3-L1 Adipogenesis by Targeting DNMT3A.
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ABSTRACT:
SUBMITTER: Zhu Y
PROVIDER: S-EPMC5256892 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Publications
Downregulated miR-29a/b/c during Contact Inhibition Stage Promote 3T3-L1 Adipogenesis by Targeting DNMT3A.
Zhu Yingjie Y Zheng Guangyong G Wang Huichao H Jia Yudong Y Zhang Ying Y Tang Yanfeng Y Li Wenlong W Fan Yanan Y Zhang Xiaodong X Liu Youwen Y Liu Sanhong S
PloS one 20170123 1
Differentiation of 3T3-L1 cells into adipocytes involves a highly-orchestrated series of events including contact inhibition (CI), clonal expansion, growth arrest, and terminal differentiation. Recent study demonstrated that 3T3-L1 preadipocytes will not be differentiated into mature adipocytes without CI stage, which indicated that CI stage plays an important role during 3T3-L1 adipogenesis. However, the molecular mechanism is not yet fully understood. In the present study, we found that the ex ...[more]
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