Quantification of spatiotemporal patterns of Ras isoform expression during development.
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ABSTRACT:
SUBMITTER: Newlaczyl AU
PROVIDER: S-EPMC5259795 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Publications
Quantification of spatiotemporal patterns of Ras isoform expression during development.
Newlaczyl Anna U AU Coulson Judy M JM Prior Ian A IA
Scientific reports 20170124
Ras proteins are important signalling hubs frequently dysregulated in cancer and in a group of developmental disorders called Rasopathies. Three Ras genes encode four proteins that differentially contribute to these phenotypes. Using quantitative real-time PCR (qRT-PCR) we have measured the gene expression profiles of each of the Ras isoforms in a panel of mouse tissues derived from a full developmental time course spanning embryogenesis through to adulthood. In most tissues and developmental st ...[more]
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