Ontology highlight
ABSTRACT:
SUBMITTER: Gutierrez-Castellanos N
PROVIDER: S-EPMC5263704 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Gutierrez-Castellanos Nicolas N Da Silva-Matos Carla M CM Zhou Kuikui K Canto Cathrin B CB Renner Maria C MC Koene Linda M C LMC Ozyildirim Ozgecan O Sprengel Rolf R Kessels Helmut W HW De Zeeuw Chris I CI
Neuron 20170101 2
Accumulating evidence indicates that cerebellar long-term potentiation (LTP) is necessary for procedural learning. However, little is known about its underlying molecular mechanisms. Whereas AMPA receptor (AMPAR) subunit rules for synaptic plasticity have been extensively studied in relation to declarative learning, it is unclear whether these rules apply to cerebellum-dependent motor learning. Here we show that LTP at the parallel-fiber-to-Purkinje-cell synapse and adaptation of the vestibulo-o ...[more]