Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC5279843 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Wang Chenhui C Yang Jiebing J Han Haobo H Chen Jiawen J Wang Yudi Y Li Quanshun Q Wang Yanbo Y
International journal of nanomedicine 20170124
In this study, poly(lactic-<i>co</i>-glycolic acid) (PLGA) was used as a carrier to construct disulfiram-loaded porous microparticle through the emulsion solvent evaporation method, using ammonium bicarbonate as a porogen. The microparticle possessed highly porous surface, suitable aerodynamic diameter for inhalation (8.31±1.33 µm), favorable drug loading (4.09%±0.11%), and sustained release profile. The antiproliferation effect of release supernatant was detected through 3-(4,5-dimethylthiazol- ...[more]