Ontology highlight
ABSTRACT:
SUBMITTER: Mor-Vaknin N
PROVIDER: S-EPMC5303823 | biostudies-other | 2017 Feb
REPOSITORIES: biostudies-other
Mor-Vaknin Nirit N Saha Anjan A Legendre Maureen M Carmona-Rivera Carmelo C Amin M Asif MA Rabquer Bradley J BJ Gonzales-Hernandez Marta J MJ Jorns Julie J Mohan Smriti S Yalavarthi Srilakshmi S Pai Dave A DA Angevine Kristine K Almburg Shelley J SJ Knight Jason S JS Adams Barbara S BS Koch Alisa E AE Fox David A DA Engelke David R DR Kaplan Mariana J MJ Markovitz David M DM
Nature communications 20170206
Novel therapeutics are required for improving the management of chronic inflammatory diseases. Aptamers are single-stranded RNA or DNA molecules that have recently shown utility in a clinical setting, as they can specifically neutralize biomedically relevant proteins, particularly cell surface and extracellular proteins. The nuclear chromatin protein DEK is a secreted chemoattractant that is abundant in the synovia of patients with juvenile idiopathic arthritis (JIA). Here, we show that DEK is c ...[more]