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Isolation of Drosophila genes encoding G protein-coupled receptor kinases.

ABSTRACT: G protein-coupled receptors are regulated via phosphorylation by a variety of protein kinases. Recently, termination of the active state of two such receptors, the beta-adrenergic receptor and rhodopsin, has been shown to be mediated by agonist- or light-dependent phosphorylation of the receptor by members of a family of protein-serine/threonine kinases (here referred to as G protein-coupled receptor kinases). We now report the isolation of a family of genes encoding a set of Drosophila protein kinases that appear to code for G protein-coupled receptor kinases. These proteins share a high degree of sequence homology with the bovine beta-adrenergic receptor kinase. The presence of a conserved family of G protein-coupled receptor kinases in vertebrates and invertebrates points to the central role of these kinases in signal transduction cascades.

SUBMITTER: Cassill JA

PROVIDER: S-EPMC53074 | biostudies-other | 1991 Dec

REPOSITORIES: biostudies-other

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Isolation of Drosophila genes encoding G protein-coupled receptor kinases.

Cassill J A JA Whitney M M Joazeiro C A CA Becker A A Zuker C S CS

Proceedings of the National Academy of Sciences of the United States of America 19911201 24

G protein-coupled receptors are regulated via phosphorylation by a variety of protein kinases. Recently, termination of the active state of two such receptors, the beta-adrenergic receptor and rhodopsin, has been shown to be mediated by agonist- or light-dependent phosphorylation of the receptor by members of a family of protein-serine/threonine kinases (here referred to as G protein-coupled receptor kinases). We now report the isolation of a family of genes encoding a set of Drosophila protein ...[more]

PMID: 1662381

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