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A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings.

ABSTRACT: The surface modification of implantable biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel-mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres and polystyrene microbeads, a model material known to produce robust foreign body responses and fibrosis, are successfully modified to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice.

SUBMITTER: Yesilyurt V

PROVIDER: S-EPMC5322155 | biostudies-other | 2017 Feb

REPOSITORIES: biostudies-other

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A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings.

Yesilyurt Volkan V Veiseh Omid O Doloff Joshua C JC Li Jie J Bose Suman S Xie Xi X Bader Andrew R AR Chen Michael M Webber Matthew J MJ Vegas Arturo J AJ Langer Robert R Anderson Daniel G DG

Advanced healthcare materials 20161215 4

The surface modification of implantable biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel-mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres and polystyrene microbeads, a model material known to produce robust foreign body responses and fibrosis, are successfully modified to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice. ...[more]

PMID: 27976536

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