Ontology highlight
ABSTRACT:
SUBMITTER: Decourt B
PROVIDER: S-EPMC5328927 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Decourt Boris B Lahiri Debomoy K DK Sabbagh Marwan N MN
Current Alzheimer research 20170101 4
Alzheimer's disease (AD) affects an estimated 44 million individuals worldwide, yet no therapeutic intervention is available to stop the progression of the dementia. Neuropathological hallmarks of AD are extracellular deposits of amyloid beta (Aβ) peptides assembled in plaques, intraneuronal accumulation of hyperphosphorylated tau protein forming tangles, and chronic inflammation. A pivotal molecule in inflammation is the pro-inflammatory cytokine TNF-α. Several lines of evidence using genetic a ...[more]