Ontology highlight
ABSTRACT:
SUBMITTER: Julius D
PROVIDER: S-EPMC53382 | biostudies-other | 1990 Feb
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19900201 3
Serotonin exerts its diverse physiological effects by interacting with multiple distinct receptor subtypes. We have isolated a rat brain 5HT2 serotonin receptor cDNA by virtue of its homology with the 5HT1c receptor. The 5HT2 receptor is a member of the family of receptors that are linked to guanine nucleotide-binding proteins and are predicted to span the lipid bilayer seven times. Overall sequence identity between the 5HT2 and 5HT1c receptors is 49%, but identity within the transmembrane domai ...[more]