Ontology highlight
ABSTRACT:
SUBMITTER: Sung LA
PROVIDER: S-EPMC53388 | biostudies-other | 1990 Feb
REPOSITORIES: biostudies-other
Sung L A LA Chien S S Chang L S LS Lambert K K Bliss S A SA Bouhassira E E EE Nagel R L RL Schwartz R S RS Rybicki A C AC
Proceedings of the National Academy of Sciences of the United States of America 19900201 3
Protein 4.2 (P4.2) comprises approximately 5% of the protein mass of human erythrocyte (RBC) membranes. Anemia occurs in patients with RBCs deficient in P4.2, suggesting a role for this protein in maintaining RBC stability and integrity. We now report the molecular cloning and characterization of human RBC P4.2 cDNAs. By immunoscreening a human reticulocyte cDNA library and by using the polymerase chain reaction, two cDNA sequences of 2.4 and 2.5 kilobases (kb) were obtained. These cDNAs differ ...[more]