Ontology highlight
ABSTRACT:
SUBMITTER: Minocha S
PROVIDER: S-EPMC5339799 | biostudies-other | 2017 Mar
REPOSITORIES: biostudies-other
Minocha Shilpi S Valloton Delphine D Arsenijevic Yvan Y Cardinaux Jean-René JR Guidi Raffaella R Hornung Jean-Pierre JP Lebrand Cécile C
Scientific reports 20170307
The homeodomain transcription factor Nkx2.1 (NK2 homeobox 1) controls cell differentiation of telencephalic GABAergic interneurons and oligodendrocytes. Here we show that Nkx2.1 also regulates astrogliogenesis of the telencephalon from embryonic day (E) 14.5 to E16.5. Moreover we identify the different mechanisms by which Nkx2.1 controls the telencephalic astrogliogenesis. In Nkx2.1 knockout (Nkx2.1<sup>-/-</sup>) mice a drastic loss of astrocytes is observed that is not related to cell death. F ...[more]