Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC4102842 | biostudies-other | 2014 Jul
REPOSITORIES: biostudies-other
Li Qian Q Zhang Pan P Zhang Chao C Wang Ying Y Wan Ru R Yang Ye Y Guo Xuejiang X Huo Ran R Lin Min M Zhou Zuomin Z Sha Jiahao J
Journal of biomedical research 20140303 4
DDX3X is a highly conserved DEAD-box RNA helicase that participates in RNA transcription, RNA splicing, and mRNA transport, translation, and nucleo-cytoplasmic transport. It is highly expressed in metaphase II (MII) oocytes and is the predominant DDX3 variant in the ovary and embryo. However, whether it is important in mouse early embryo development remains unknown. In this study, we investigated the function of DDX3X in early embryogenesis by cytoplasmic microinjection with its siRNA in zygotes ...[more]