Ontology highlight
ABSTRACT:
SUBMITTER: Shin DW
PROVIDER: S-EPMC5340543 | biostudies-other | 2017 Mar
REPOSITORIES: biostudies-other
Shin Dong-Won DW Kwon Yeo-Jung YJ Ye Dong-Jin DJ Baek Hyoung-Seok HS Lee Joo-Eun JE Chun Young-Jin YJ
Biomolecules & therapeutics 20170301 2
Auranofin has been developed as antirheumatic drugs, which is currently under clinical development for the treatment of chronic lymphocytic leukemia. Previous report showed that auranofin induced apoptosis by enhancement of annexin A5 expression in PC-3 cells. To understand the role of annexin A5 in auranofin-mediated apoptosis, we performed microarray data analysis to study annexin A5-controlled gene expression in annexin A5 knockdown PC-3 cells. Of differentially expressed genes, plasminogen a ...[more]