Ontology highlight
ABSTRACT:
SUBMITTER: Baek HS
PROVIDER: S-EPMC5650338 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Baek Hyoung-Seok HS Park Nahee N Kwon Yeo-Jung YJ Ye Dong-Jin DJ Shin Sangyun S Chun Young-Jin YJ
Oncotarget 20170719 43
Annexin A5 (ANXA5) is a member of the annexin protein family. Previous studies have shown that ANXA5 is involved in anti-inflammation and cell death. However, the detailed mechanism of the role of ANXA5 in cancer cells is not well understood. In this study, we investigated the inhibitory effect of ANXA5 on cyclooxygenase-2 (COX-2) in prostate cancer cells. Expression of COX-2 induced by TNF-α was inhibited by overexpression of ANXA5 and inhibition of COX-2 expression by auranofin, which could in ...[more]