Ontology highlight
ABSTRACT:
SUBMITTER: Hu J
PROVIDER: S-EPMC5342007 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Hu Jiangang J Zhang Xiang X Wen Zuhuang Z Tan Ying Y Huang Ning N Cheng Si S Zheng Huzhi H Cheng Yuan Y
Oncotarget 20161101 45
The blood-brain barrier (BBB) is the major clinical obstacle in the chemotherapeutic management of brain glioma. Here we synthesized a pH-sensitive dual-targeting doxorubicin (DOX) carrier to compromise tumor endothelial cells, enhance BBB transportation, and improve drug accumulation in glioma cells. The drug delivery system was constructed with polydopamine (PDA)-coated mesoporous silica nanoparticles (NPs, MSNs) and the PDA coating was functionalized with Asn-Gly-Arg (NGR), a ligand with spec ...[more]