Ontology highlight
ABSTRACT:
SUBMITTER: Mrad M
PROVIDER: S-EPMC5342129 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Mrad Marguerite M Imbert Caroline C Garcia Virginie V Rambow Florian F Therville Nicole N Carpentier Stéphane S Ségui Bruno B Levade Thierry T Azar Rania R Marine Jean-Christophe JC Diab-Assaf Mona M Colacios Céline C Andrieu-Abadie Nathalie N
Oncotarget 20161101 44
The infiltration of melanoma tumors by macrophages is often correlated with poor prognosis. However, the molecular signals that regulate the dialogue between malignant cells and the inflammatory microenvironment remain poorly understood. We previously reported an increased expression of sphingosine kinase-1 (SK1), which produces the bioactive lipid sphingosine 1-phosphate (S1P), in melanoma. The present study aimed at defining the role of tumor SK1 in the recruitment and differentiation of macro ...[more]