Ontology highlight
ABSTRACT:
SUBMITTER: Tiyaboonchai A
PROVIDER: S-EPMC5355564 | biostudies-other | 2017 Mar
REPOSITORIES: biostudies-other
Stem cell reports 20170209 3
Induced pluripotent stem cells were created from a pancreas agenesis patient with a mutation in GATA6. Using genome-editing technology, additional stem cell lines with mutations in both GATA6 alleles were generated and demonstrated a severe block in definitive endoderm induction, which could be rescued by re-expression of several different GATA family members. Using the endodermal progenitor stem cell culture system to bypass the developmental block at the endoderm stage, cell lines with mutatio ...[more]