Ontology highlight
ABSTRACT:
SUBMITTER: Gupta N
PROVIDER: S-EPMC5369337 | biostudies-other | 2017 Mar
REPOSITORIES: biostudies-other
Chemical science 20161209 3
Despite the advances in the design of antibody-drug conjugates (ADCs), the search is still ongoing for novel approaches that lead to increased stability and homogeneity of the ADCs. We report, for the first time, an ADC platform technology using a platinum(ii)-based linker that can re-bridge the inter-chain cysteines in the antibody, post-reduction. The strong platinum-sulfur interaction improves the stability of the ADC when compared with a standard maleimide-linked ADC thereby reducing the lin ...[more]