Ontology highlight
ABSTRACT:
SUBMITTER: Singh AK
PROVIDER: S-EPMC5373882 | biostudies-other | 2017 Apr
REPOSITORIES: biostudies-other
Singh Anand Kumar AK Zajdel Joanna J Mirrasekhian Elahe E Almoosawi Nader N Frisch Isabell I Klawonn Anna M AM Jaarola Maarit M Fritz Michael M Engblom David D
The Journal of clinical investigation 20170313 4
Pain is fundamentally unpleasant and induces a negative affective state. The affective component of pain is mediated by circuits that are distinct from those mediating the sensory-discriminative component. Here, we have investigated the role of prostaglandins in the affective dimension of pain using a rodent pain assay based on conditioned place aversion to formalin injection, an inflammatory noxious stimulus. We found that place aversion induced by inflammatory pain depends on prostaglandin E2 ...[more]