Ontology highlight
ABSTRACT:
SUBMITTER: McVicker DP
PROVIDER: S-EPMC5411814 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Nature communications 20160923
Synaptic plasticity often involves changes in the structure and composition of dendritic spines. Vesicular cargos and organelles enter spines either by exocytosing in the dendrite shaft and diffusing into spines or through a kinesin to myosin hand-off at the base of spines. Here we present evidence for microtubule (MT)-based targeting of a specific motor/cargo pair directly into hippocampal dendritic spines. During transient MT polymerization into spines, the kinesin KIF1A and an associated carg ...[more]