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Pre-mRNA mis-splicing of sarcomeric genes in heart failure.

ABSTRACT: Pre-mRNA splicing is an important biological process that allows production of multiple proteins from a single gene in the genome, and mainly contributes to protein diversity in eukaryotic organisms. Alternative splicing is commonly governed by RNA binding proteins to meet the ever-changing demands of the cell. However, the mis-splicing may lead to human diseases. In the heart of human, mis-regulation of alternative splicing has been associated with heart failure. In this short review, we focus on alternative splicing of sarcomeric genes and review mis-splicing related heart failure with relatively well studied Sarcomeric genes and splicing mechanisms with identified regulatory factors. The perspective of alternative splicing based therapeutic strategies in heart failure has also been discussed.

SUBMITTER: Zhu C

PROVIDER: S-EPMC5419885 | biostudies-other | 2017 Aug

REPOSITORIES: biostudies-other

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Pre-mRNA mis-splicing of sarcomeric genes in heart failure.

Zhu Chaoqun C Chen Zhilong Z Guo Wei W

Biochimica et biophysica acta. Molecular basis of disease 20161105 8

Pre-mRNA splicing is an important biological process that allows production of multiple proteins from a single gene in the genome, and mainly contributes to protein diversity in eukaryotic organisms. Alternative splicing is commonly governed by RNA binding proteins to meet the ever-changing demands of the cell. However, the mis-splicing may lead to human diseases. In the heart of human, mis-regulation of alternative splicing has been associated with heart failure. In this short review, we focus ...[more]

PMID: 27825848

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