[18F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease.
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ABSTRACT:
SUBMITTER: James ML
PROVIDER: S-EPMC5436503 | biostudies-other | 2017
REPOSITORIES: biostudies-other
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[<sup>18</sup>F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease.
James Michelle L ML Belichenko Nadia P NP Shuhendler Adam J AJ Hoehne Aileen A Andrews Lauren E LE Condon Christina C Nguyen Thuy-Vi V TV Reiser Vladimer V Jones Paul P Trigg William W Rao Jianghong J Gambhir Sanjiv S SS Longo Frank M FM
Theranostics 20170324 6
Microglial activation is a key pathological feature of Alzheimer's disease (AD). PET imaging of translocator protein 18 kDa (TSPO) is a strategy to detect microglial activation <i>in vivo</i>. Here we assessed flutriciclamide ([<sup>18</sup>F]GE-180), a new second-generation TSPO-PET radiotracer, for its ability to monitor response to LM11A-31, a novel AD therapeutic in clinical trials. AD mice displaying pathology were treated orally with LM11A-31 for 3 months. Subsequent [<sup>18</sup>F]GE-180 ...[more]
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