Ontology highlight
ABSTRACT:
SUBMITTER: Jacquin E
PROVIDER: S-EPMC5446083 | biostudies-other | 2017 May
REPOSITORIES: biostudies-other
Jacquin Elise E Leclerc-Mercier Stéphanie S Judon Celine C Blanchard Emmanuelle E Fraitag Sylvie S Florey Oliver O
Autophagy 20170215 5
The modulation of canonical macroautophagy/autophagy for therapeutic benefit is an emerging strategy of medical and pharmaceutical interest. Many drugs act to inhibit autophagic flux by targeting lysosome function, while others were developed to activate the pathway. Here, we report the surprising finding that many therapeutically relevant autophagy modulators with lysosomotropic and ionophore properties, classified as inhibitors of canonical autophagy, are also capable of activating a parallel ...[more]