Dataset Information

Preparation and Properties of Electrospun Poly (Vinyl Pyrrolidone)/Cellulose Nanocrystal/Silver Nanoparticle Composite Fibers.

ABSTRACT: Poly (vinyl pyrrolidone) (PVP)/cellulose nanocrystal (CNC)/silver nanoparticle composite fibers were prepared via electrospinning using N,N'-dimethylformamide (DMF) as a solvent. Rheology, morphology, thermal properties, mechanical properties, and antimicrobial activity of nanocomposites were characterized as a function of material composition. The PVP/CNC/Ag electrospun suspensions exhibited higher conductivity and better rheological properties compared with those of the pure PVP solution. The average diameter of the PVP electrospun fibers decreased with the increase in the amount of CNCs and Ag nanoparticles. Thermal stability of electrospun composite fibers was decreased with the addition of CNCs. The CNCs help increase the composite tensile strength, while the elongation at break decreased. The composite fibers included Ag nanoparticles showed improved antimicrobial activity against both the Gram-negative bacterium Escherichia coli (E. coli) and the Gram-positive bacterium Staphylococcus aureus (S. aureus). The enhanced strength and antimicrobial performances of PVP/CNC/Ag electrospun composite fibers make the mat material an attractive candidate for application in the biomedical field.

SUBMITTER: Huang S

PROVIDER: S-EPMC5456859 | biostudies-other | 2016 Jun

REPOSITORIES: biostudies-other

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Preparation and Properties of Electrospun Poly (Vinyl Pyrrolidone)/Cellulose Nanocrystal/Silver Nanoparticle Composite Fibers.

Huang Siwei S Zhou Ling L Li Mei-Chun MC Wu Qinglin Q Kojima Yoichi Y Zhou Dingguo D

Materials (Basel, Switzerland) 20160628 7

Poly (vinyl pyrrolidone) (PVP)/cellulose nanocrystal (CNC)/silver nanoparticle composite fibers were prepared via electrospinning using <i>N</i>,<i>N</i>'-dimethylformamide (DMF) as a solvent. Rheology, morphology, thermal properties, mechanical properties, and antimicrobial activity of nanocomposites were characterized as a function of material composition. The PVP/CNC/Ag electrospun suspensions exhibited higher conductivity and better rheological properties compared with those of the pure PVP ...[more]

PMID: 28773644

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Project description:Controlled delivery of hydrophilic proteins is an important therapeutic strategy. However, widely used methods for protein delivery suffer from low incorporation efficiency and loss of bioactivity. The versatile interfacial polyelectrolyte complexation (IPC) fibers have the capacity for precise spatiotemporal release and protection of protein, growth factor, and cell bioactivity. Yet its weak mechanical properties limit its application and translation into a viable clinical solution. To overcome this limitation, IPC fibers can be incorporated into polymeric scaffolds such as the biocompatible poly(vinyl alcohol) hydrogel (PVA). Therefore, we explored the use of a composite scaffold of PVA and IPC fibers for controlled biomolecule release. We first observed that the permeability of biomolecules through PVA films were dependent on molecular weight. Next, IPC fibers were incorporated in between layers of PVA to produce PVA-IPC composite scaffolds with different IPC fiber orientation. The composite scaffold demonstrated excellent mechanical properties and efficient biomolecule incorporation. The rate of biomolecule release from PVA-IPC composite grafts exhibited dependence on molecular weight, with lysozyme showing near-linear release for 1?month. Angiogenic factors were also incorporated into the PVA-IPC grafts, as a potential biomedical application of the composite graft. While vascular endothelial growth factor only showed a maximum cumulative release of 3%, the smaller PEGylated-QK peptide showed maximum release of 33%. Notably, the released angiogenic biomolecules induced endothelial cell activity thus indicating retention of bioactivity. We also observed lack of significant macrophage response against PVA-IPC grafts in a rabbit model. Showing permeability, mechanical strength, precise temporal growth factor release, and bioinertness, PVA-IPC fibers composite scaffolds are excellent scaffolds for controlled biomolecule delivery in soft tissue engineering.

Dataset Information

Preparation and Properties of Electrospun Poly (Vinyl Pyrrolidone)/Cellulose Nanocrystal/Silver Nanoparticle Composite Fibers.

Publications

Preparation and Properties of Electrospun Poly (Vinyl Pyrrolidone)/Cellulose Nanocrystal/Silver Nanoparticle Composite Fibers.

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