The N-terminal to C-terminal motif in protein folding and function.
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ABSTRACT:
SUBMITTER: Krishna MM
PROVIDER: S-EPMC545867 | biostudies-other | 2005 Jan
REPOSITORIES: biostudies-other
Publications
The N-terminal to C-terminal motif in protein folding and function.
Krishna Mallela M G MM Englander S Walter SW
Proceedings of the National Academy of Sciences of the United States of America 20050118 4
Essentially all proteins known to fold kinetically in a two-state manner have their N- and C-terminal secondary structural elements in contact, and the terminal elements often dock as part of the experimentally measurable initial folding step. Conversely, all N-C no-contact proteins studied so far fold by non-two-state kinetics. By comparison, about half of the single domain proteins in the Protein Data Bank have their N- and C-terminal elements in contact, more than expected on a random probabi ...[more]
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