Ontology highlight
ABSTRACT:
SUBMITTER: Amin M
PROVIDER: S-EPMC5462461 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
Amin Matthew M Pushpakumar Sathnur S Muradashvili Nino N Kundu Sourav S Tyagi Suresh C SC Sen Utpal U
Frontiers in bioscience (Landmark edition) 20160101 1
Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases whose main function is to degrade and deposit structural proteins within the extracellular matrix (ECM). A dysregulation of MMPs is linked to vascular diseases. MMPs are classified into collagenases, gelatinases, membrane-type, metalloelastase, stromelysins, matrilysins, enamelysins, and unclassified subgroups. The production of MMPs is stimulated by factors such as oxidative stress, growth factors and inflammation wh ...[more]