Ontology highlight
ABSTRACT:
SUBMITTER: Woo JA
PROVIDER: S-EPMC5467170 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Nature communications 20170606
Although multiple CHCHD10 mutations are associated with the spectrum of familial and sporadic frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) diseases, neither the normal function of endogenous CHCHD10 nor its role in the pathological milieu (that is, TDP-43 pathology) of FTD/ALS have been investigated. In this study, we made a series of observations utilizing Caenorhabditis elegans models, mammalian cell lines, primary neurons and mouse brains, demonstrating that CHCHD10 normall ...[more]